Phylogenetics (EEB 5349)
This is a graduate-level course in phylogenetics, emphasizing primarily maximum likelihood and Bayesian approaches to estimating phylogenies, which are genealogies at or above the species level. A primary goal is to provide an accessible introduction to the theory so that by the end of the course students should be able to understand much of the primary literature on modern phylogenetic methods and know how to intelligently apply these methods to their own problems. The laboratory provides hands-on experience with several important phylogenetic software packages (PAUP*, IQ-TREE, RevBayes, BayesTraits, and others) and introduces students to the use of remote high performance computing resources to perform phylogenetic analyses.
Semester: Spring 2024
Lecture: Tuesday/Thursday 11:00-12:15 (Paul O. Lewis, office hours Tu 1-2 or by appointment in Gant w421)
Lab: Thursday 1:25-3:20 (Analisa Milkey, office hours: Mo 1:30-2:30, Fr 12-1 in Gant W420)
Room: Torrey Life Science (TLS) 181, Storrs Campus
Text: Lewis, P. O. 2024. Getting Rooted in Bayesian Phylogenetics (unfinished, but some chapters are ready)
Schedule
Warning: This schedule will most likely change quite a few times during the semester.
Index to major topics
Literature cited
Grading
Books (and book chapters) on phylogenetics
This is a list of books that you should know about, but none are required texts for this course. Listed in reverse chronological order.
LJ Revell and LJ Harmon. 2022. Phylogenetic comparative methods in R. Princeton University Press. ISBN:978-0-691-21903-5
L Harmon. 2019. Phylogenetic comparative methods. (Version 1.4, released 15 March 2019). Published online by the author.
AJ Drummond and RR Bouckaert. 2015. Bayesian evolutionary analysis with BEAST, Cambridge University Press. ISBN:978-1-139-09511-2
Z Yang. 2014. Molecular evolution: a statistical approach. Oxford University Press. ISBN:978-0-199-60261-0
LZ Garamszegi. 2014. Modern phylogenetic comparative methods and their application in evolutionary biology: concepts and practice. Springer-Verlag, Berlin. ISBN:978-3-662-43549-6 (Well-written chapters by current leaders in phylogenetic comparative methods.)
DA Baum and SD Smith. 2013. Tree thinking: an introduction to phylogenetic biology. Roberts and Company Publishers, Greenwood Village, Colorado. ISBN:978-1-936-22116-5 (This book is a useful companion volume for this course, introducing the methods in a very accessible way but also providing lots of practice interpreting phylogenies correctly.)
BG Hall. 2011. Phylogenetic trees made easy: a how-to manual (4th edition). Sinauer Associates, Sunderland. ISBN:978-0-878-93606-9 (A guide to running some of the most important phylogenetic software packages.)
P Lemey, M Salemi, and AM Vandamme. 2009. The phylogenetic handbook: a practical approach to phylogenetic analysis and hypothesis testing (2nd edition). ISBN:978-0-511-81904-9 Cambridge University Press, Cambridge, UK (Chapters on theory are paired with practical chapters on software related to the theory.)
J Felsenstein. 2004. Inferring phylogenies. Sinauer Associates, Sunderland. ISBN:978-0-878-93177-4 (Comprehensive overview of both history and methods of phylogenetics.)
R Page and E Holmes. 1998. Molecular evolution: a phylogenetic approach. Blackwell Science. ISBN:978-0-865-42889-8 (Very accessible pre-Bayesian-era introduction to the field.)
D Hillis, C Moritz, and B Mable. 1996. Molecular systematics (2nd ed.). Sinauer Associates, Sunderland. ISBN:978-0-878-93282-5 (Still a very valuable compendium of pre-Bayesian-era phylogenetic methods.)
DL Swofford, GJ Olsen, PJ Waddell, and DM Hillis. 1996. Chapter 11: Phylogenetic inference. Pages 407-514 in Molecular Systematics (D. M. Hillis, C. Moritz, and B. K. Mable, eds.). Sinauer Associates, Sunderland, Massachusetts. ISBN:978-0-878-93282-5 (Excellent reference for pre-Bayesian phylogenetics; original description of the SOWH topology test)